Clinical Application of a Test for Lupus Globulin-Nucleohistone Interaction Using Fluorescent Antibody **

نویسنده

  • George J. Friou
چکیده

In studies reported elsewhere we have demonstrated by the fluorescent antibody technique that serum of patients with disseminated lupus erythematosus contains a globulin factor with a marked affinity for nuclei.7'8 In further investigation of this reaction it was shown that the component of nuclei involved was in the nucleoprotein fraction." During this study a method for titration of this activity of sera was developed which utilized a nucleoprotein extract of calf thymus. With this method it -was possible to obtain reproducible titration of activity of sera in a more refined system than that involving intact nuclei. A preliminary study indicated that an extensive survey of the occurrence of this factor in human sera would be of interest.' These results are the subject of the present report.

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 31  شماره 

صفحات  -

تاریخ انتشار 1958